Naturally Occurring Compounds With Larvicidal Activity Against Malaria Mosquitoes

Female Anopheles mosquitoes transmit Plasmodium parasites that cause human malaria. Currently, vector control is the most widely deployed approach to reduce mosquito population and hence disease transmission. This relies on use of insecticide-based interventions including Long-lasting Insecticide-treated Nets (LLINs) Indoor Residual Spraying (IRS) where scale-up has contributed a dramatic decline in malaria deaths morbidity over past decade. Challenges their effective include emergence spread insecticide resistance by populations coupled with inability curb outdoor Under these situations, larvicides through larval source management (LSM) can complement existing measures. The need minimize environmental impact effect non-target organisms spurred interest development eco-friendly natural origin. Here, we review literature published last five years highlight compounds origin found exhibit larvicidal activity against mosquitoes. Specifically, different classes discussed organisms. Additionally, provide suggestions for future research into chemical synthesis improve bioactivity known compounds.